![]() ![]() ![]() In a secondary analysis of this trial, the authors also found that a third dose of vaccine augmented neutralizing antibody responses against the Alpha, Beta and Delta variants ( Kumar, November 2021). ![]() Additionally, after the study intervention, the median percentage virus neutralization was 71% in the vaccine group compared with only 13% in the placebo group ( Hall, August 2021). At 1 month after the study intervention, 55% (33 of 60) recipients of a third dose of Moderna COVID-19 vaccine achieved that concentration, compared with only 18% (10 of 57) in the placebo group. Immunogenicity data were available from 117 subjects prior to the study intervention, only 11.7% and 8.8% of the treatment and placebo groups respectively had an antireceptor binding domain antibody concentration above a prespecified threshold of 100 U/mL. In a randomized controlled trial of 120 solid organ transplant recipients, subjects who had previously completed a two-dose series of the Moderna COVID-19 vaccine were randomized 1:1 to receive a third dose of vaccine or saline placebo 2 months after the second dose of the primary vaccine series.Key primary studies that have evaluated the effect of additional doses of COVID-19 vaccines as part of a primary series in immunocompromised populations include: mRNA vaccines Immunocompromised PopulationsįDA has authorized and CDC recommends an additional dose of COVID-19 mRNA vaccine as part of the primary series for certain immunocompromised populations. ![]() Moderately or severely immunocompromised individuals who receive Novavax as the primary series are no w recommended to receive a bivalent booster at least 2 months after completion of the primary series. T his equates to a third mRNA vaccine dose in the primary series for those who received Pfizer-BioNTech or Moderna for individuals with a single-dose J&J/Janssen primary series, this equates to a second vaccine dose in the primary series. recommends a routine additional dose of mRNA vaccine as part of the primary series. * Only if patient is medically ineligible for another COVID-19 vaccine and/or would otherwise not receive any COVID-19 vaccine.įor individuals receiving a Moderna, Pfizer-BioNTech or J&J/Janssen primary series who are moderately to severely immunocompromised, the U.S. COVID-19 Vaccine Dosing & Schedule: Immunocompromised * Only if patient is medically ineligible for another COVID-19 vaccine and/or would otherwise not receive any COVID-19 vaccine. Pfizer-BioNTech and Moderna products may be used interchangeably for adult booster doses. COVID-19 Vaccine Dosing & Schedule: NonimmunocompromisedĬolor code: Green = primary series blue = booster dose(s).Īll listed time intervals represent the minimum recommended interval. The very small risk of myocarditis, especially for males aged 12-39 years, may be further reduced with an extended interval between primary doses. However, given concerns about waning immunity and the emergence of novel variants, there is interest in understanding the potential role of alternative dosing strategies for these vaccines to augment or prolong their protective effect, including (but not limited to) administration of additional doses of each vaccine, schedules containing different products (“mix and match”) and modified dosing intervals.Īlthough individuals aged 12 years and up (for Pfizer-BioNTech) and individuals aged 18 years and up (for Moderna) may receive the second dose in the primary series at extended intervals, shorter intervals are still recommended for moderately to severely immunocompromised individuals, adults aged 65 and older and others who need rapid protection. All four vaccines have been demonstrated to be highly effective against severe outcomes related to COVID-19 in clinical trials and postauthorization observational studies. The four COVID-19 vaccines available for use in the U.S. It is not comprehensive of all data related to this subject. The following is a curated review of key information and literature about this topic. Immunocompromised Dosing & Schedule Table.Nonimmunocompromised Dosing & Schedule Table. ![]()
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